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spironolactone

n.
1.a synthetic corticosteroid (trade name Aldactone) used to treat hypertension

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    at the top of the hour
    at the beginning of the hour - 12:00, 1:00 etc. (at the top of a clock)
    The radio news always starts at the top of the hour.



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    The college was closed because numbers had been ________ off for years

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