DO generally refers to the action itself, and MAKE usually implies that there is a result. For example, if you "make breakfast," the result is an omelet! If you "make a suggestion," you have created a recommendation.

Use DO for actions, obligations, and repetitive tasks:

do the laundry

do homework

do the shopping

do business

do well / do badly (in general)

do the right thing

Use MAKE for creating or producing something, and for actions you choose to do:

make breakfast/lunch/dinner

make your own peanut butter

make money (= earn money)

make friends (= meet people and start friendships)

make a suggestion/comment/complaint/confession/excuse/promise

make plans

make a list

make a decision

Science Facts
A common cure for all kinds of illnesses in the past was ‘bleeding' the patient. This could be done by the doctor making a small cut and putting a hot cup over the wound to suck out blood, or by putting blood-sucking leeches on the skin. Using leeches is being reintroduced by some western doctors.      .. More >>