1. What's the matter?
2. What's wrong?
3. Are you all right?
4. You look a bit down. (= a little sad)
5. Is there anything I can do to help?
6. Cheer up! / Chin up!
7. It's not so bad.
8. Everything will be OK.
9. Look on the bright side. (= consider the positive aspects)
10. It's not the end of the world. (this phrase is used when someone is upset about something small and trivial)

Fact
The estimated weight of the Great Pyramid of Egypt is 6,648,000 tons.      .. More >>